Publications​

2018

Fredriksson I and Li X (2018) Rate matters: rapid cocaine delivery potentiates incubation of cocaine craving. Neuropsychopharmacology.( PDF

Cates HM*, Li X*, Purushothaman I, Kennedy PJ, Shen L, Shaham Y, Nestler EJ (2018) Genome-wide transcriptional profiling of central amygadala and obitofrontal cortex during incubation of methamphetamine craving. Neuropsychopharmacology. ( PDF ) *Equal contribution

Li X, Witonsky K, Surjono F, Lofaro OM, Zhang J, Bossert JM, Shaham Y (2018) Role of anterior intralaminar nuclei of thalamus projections to dorsomedial striatum in incubation of methamphetamine craving. Journal of Neuroscience.  PMID: 29371321 ( PDF )

Li X, Carreria MB, Witonsky KF, Zeric T, Lofaro OM, Bossert JM, Zhang J, Surjono F, Richie CT, Harvey BK, Son H, Cowan CW, Nestler EJ, Shaham Y (in press) Role of dorsal striatal histone deacetylase 5 in incubation of methamphetamine craving. Biological Psychiatry. PMID:29397902 (
PDF )

2017

Zhang W, Daly KM, Liang B, Zhang LF, Li X, Li Y, Lin DT (2017) BDNF rescues prefrontal dysfunction elicited by pyramidal neuron-specific DTNBP1 deletion in vivo. Journal of Molecular Cell Biology 9: 117-131. PMID: 27330059 ( PDF ).

2016

Rubio FJ*, Li X*, Liu QR, Cimbro R, Hope BT (2016) Fluorescence activated cell sorting (FACS) and gene expression analysis of Fos-expressing neurons from fresh and frozen rat brain tissue. Journal of Visual Experiments doi:10.3791/54358. PMID: 27685012 ( PDF ). *Equal contribution

Li X, Venniro M, Shaham Y (2016) Translational research on incubation of cocaine craving. JAMA Psychiatry 73:1115-1116. PMID: 27604057 ( PDF ).  

2015

Li X, Wolf ME (2015) Multiple faces of BDNF in cocaine addiction. Behavioral Brain Research 279C: 240-254. PMID: 25449839 ( PDF ).

Li X, Zeric T, Kambhampati S, Bossert JM, Shaham Y (2015) The central amygdala nucleus is critical for incubation of methamphetamine craving. Neuropsychopharmacology 40:1297-1306. PMID: 25475163 ( PDF ).

Li X, Rubio FJ, Zeric T, Bossert JM, Cates H, Kennedy P, Liu QR, Cimbro R, Nestler EJ, Hope BT, Shaham Y (2015) Incubation of methamphetamine craving is associated with selective increases in expression of BDNF and TrkB, glutamate receptors, and epigenetic enzymes in cue-activated Fos-expressing dorsal striatal neurons. Journal of Neuroscience 35, 8232-8244. PMID: 26019338 (
PDF ).

Caprioli D, Venniro M, Zeric T, Li X, Adhikary S, Madangopal R, Marchant NJ, Lucantonia F, Schoembaum G, Bossert JM, Shaham Y (2015) Effect of the novel positive allosteric modulator of mGluR2 AZD8529 on incubation of methamphetamine craving after prolonged voluntary abstinence in a rat model. Biological Psychiatry 78:463-473. PMID: 25861699 ( PDF ).

Rubio FJ, Liu QR, Li X, Cruz F, Leao RM, Warren B, Kambhampati S, Babin K, McPherson K, Cimbro R, Bossert J, Shaham Y, Hope B (2015) Context-induced reinstatement of methamphetamine seeking is associated with unique molecular alterations in Fos-expressing dorsolateral striatum neurons. Journal of Neuroscience 35:5625-5639. PMID: 25855177 (
PDF ).

2014

Loweth JA, Scheyer AF, Milovanovic M, Lacrosse AL, Flores-Barrera E, Werner CT, Li X, Ford KA, Le T, Olive MF, Szumlinski KK, Tseng KY, Wolf ME (2014) Synaptic depression via mGluR1 positive allosteric modulation suppresses cue-induced cocaine craving. Nature Neuroscience 17, 73-80. PMID: 24270186 ( PDF ).

Li X, Caprioli D, Marchant NJ (2014) Recent updates on incubation of drug craving: a mini-review. Addiction Biology 20: 872-876. PMID: 25440081 ( PDF ).

Li X, Marchant NJ, Shaham, Y (2014) Opposing roles of cotransmission of dynorphin and hypocretin on reward and motivation. Proceedings of National Academy of Sciences of the United States of America 111: 5765-5766. PMID: 24706899 ( PDF ).

2013

Li X, DeJoseph MR, Urban JH, Bahi A, Dreyer JL, Meredith GE, Ford, KA, Loweth JA, Ferrario CR, Wolf ME (2013) Different roles of BDNF in nucleus accumbens core versus shell during the incubation of cue-induced cocaine craving and its long-term maintenance. Journal of Neuroscience 33, 1130-1142. PMID: 23325250 ( PDF ).

Theberge FR, Li X, Kambhampati S, Pickens CL, St Laurent R, Bossert JM, Baumann MH, Hutchinson MR, Rice KC, Watkins LR, Shaham Y (2013) Effect of chronic delivery of the Toll-like receptor 4 antagonist (+)-naltrexone on incubation of heroin craving. Biological Psychiatry 73, 729-737. PMID: 23384483 (
PDF ).

Marchant NJ, Li X, Shaham Y (2013) Recent developments in animal models of drug relapse. Current Opinion in Neurobiology 23, 675-683. PMID: 23374536 ( PDF )

Plaza-Zabala A, Li X, Milovanovic M, Loweth JA, Maldonado R, Berrendero F, Wolf ME (2013) An investigation of interactions between hypocretin/orexin signaling and glutamate receptor surface expression in the rat nucleus accumbens under basal conditions after cocaine exposure. Neuroscience letters 557 Pt B, 101-106. PMID: 24262606 ( PDF ).

2011

Li X, Wolf ME (2011) Brain-derived neurotrophic factor rapidly increases AMPA receptor surface expression in rat nucleus accumbens. European Journal of Neuroscience 34, 190-198. PMID: 21692887 ( PDF ).

Li X, Wolf ME (2011) Visualization of virus-infected brain regions using a GFP-illuminating flashlight enables accurate and rapid dissection for biochemical analysis. Journal of Neuroscience Methods 201, 177-179. PMID: 21816173 (
PDF) .

Ferrario CR, Li X, Wolf ME (2011) Effects of acute cocaine or dopamine receptor agonists on AMPA receptor distribution in the nucleus accumbens. Synapse 65, 54-63. PMID: 20506566 ( PDF ).

Hanson LR, Hafez D, Svitak AL, Burns RB, Li X, Frey WH 2nd, Marr RA (2011) Intranasal phosphoramidon increases beta-amyloid levels in wild-type and NEP/NEP2-deficient mice. Journal of Molecular Neuroscience 43,424-427. PMID: 20941644 (PDF).

2009

Ferrario CR, Li X, Wang X, Reimers JM, Uejima JL, Wolf ME (2009) The role of glutamate receptor redistribution in locomotor sensitization to cocaine. Neuropsychopharmacology 35, 818-833. PMID: 19924109 ( PDF ).

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